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PLAN (PLA2G6-associated neurodegeneration) is one of the NBIA (neurodegeneration with brain iron accumulation) disorders. Based on an individual’s age of onset and symptoms, they may be classified as having one of three subtypes of PLAN: INAD, aNAD or PLA2G6-related dystonia-parkinsonism. However, as we learn more about PLAN, we have found that some people fall between these categories. In other words, there is a broad spectrum of symptoms that is really a continuum.

The symptoms of INAD (infantile neuroaxonal dystrophy) usually start to appear between the ages of 6 months and 1 year…

The symptoms of aNAD (atypical neuroaxonal dystrophy) are more variable than those of INAD. Individuals typically start showing symptoms in early childhood, usually by 4 years of age…

PLA2G6-related dystonia-parkinsonism
The symptoms of PLA2G6-related dystonia-parkinsonism can start to appear anytime between childhood and early adulthood, but the majority begin in the late teens to 20s…

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